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Cardiac Regeneration (Cardiac and Vascular Biology) de Masaki Ieda,Wolfram-Hubertus Zimmermann
Descripción - Reseña del editor This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair.Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged.The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. Contraportada This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair.Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged.The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration. Biografía del autor Maskai Ieda is Associate Professor, Department of Medicine, Keio University School of Medicine, Tokyo, JapanWolfram H. Zimmermann is Professor and Director of the Institute of Pharmacology, Heart Research Center Georg-August University Göttingen, Germany.
Detalles del Libro
- Name: Cardiac Regeneration (Cardiac and Vascular Biology)
- Autor: Masaki Ieda,Wolfram-Hubertus Zimmermann
- Categoria: Libros,Libros universitarios y de estudios superiores,Medicina y ciencias de la salud
- Tamaño del archivo: 10 MB
- Tipos de archivo: PDF Document
- Descargada: 637 times
- Idioma: Español
- Archivos de estado: AVAILABLE
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Cardiac Regeneration / Circulation Research ~ Murine cardiac regeneration capacity remains robust into the first postnatal week of life, as hearts injured by apical resection on postnatal day 1 efficiently replenish the lost cardiomyocytes, resulting in hearts with minimal residual scar and with normal heart morphology and function by 1 month of life. 126,133 Although multiple groups have reproduced this result, 153 confirmation has not .
Cardiac Regeneration - PubMed Central (PMC) ~ 2. Cell Therapy and Heart Regeneration. Cardiomyocyte proliferation is the dominant mechanism for cardiac growth throughout the first several days of life in rodent model systems, while cardiomyocyte hypertrophy and limited cell division is the hallmark of juvenile and adult hearts (discussed later) (Adler and Costabel, 1975; Li et al., 1996).Given the relative scarcity of natural .
Mechanisms of Cardiac Repair and Regeneration ~ TACTICS recently produced a consensus statement prelude to topic-specific articles asserting need for a thorough understanding of mechanisms involved in myocardial repair and regeneration. 1 Serving this purpose, we offer an overview of key mechanisms involved in cardiac repair and regeneration including (1) survival and protection, (2) inflammation reduction, (3) cell–cell communication, (4 .
Medical imaging for cardiac regeneration using resident ~ Medical imaging for cardiac regeneration using resident cardiac stem cells Resident progenitor/cardiac stem cells (CSCs) are known to improve cardiac function through differentiation into cardiomyocytes and vascular lineages. To evaluate the effects of transplanted CSCs, appropriate
Cardiac Tissue Regeneration - an overview / ScienceDirect ~ One of the major hurdles in cardiac tissue regeneration is that cardiomyocytes do not proliferate, and it is not trivial to obtain sufficient number of cardiomyocytes (Mollova et al., 2013); therefore, stem cell engineering for sufficient and practical derivation of stable cardiac cells will be the key factor in further advancements for cardiac tissue bioprinting.
Cardiac Regeneration - ScienceDirect ~ The extent of regeneration after cardiac injury varied among the reports on the topic, but a synthesis of these and more recent findings highlights a sharp contrast with responses by mammals. Markers of cell proliferation such as 3 H-thymidine and BrdU incorporation were detected in cardiomyocytes, as were presence of mitotic figures ( Flink, 2002 , Oberpriller and Oberpriller, 1974 ).
Developing insights into cardiac regeneration / Development ~ Owing to its intrinsic beauty and biomedical importance, the heart has been the focus of intensive research. The recent EMBO/EMBL-sponsored symposium ‘Cardiac Biology: From Development to Regeneration’ gathered cardiovascular scientists from across the globe to discuss the latest advances in our understanding of the development and growth of the heart, and application of these advances to .
Cardiac and Vascular Biology - springer ~ This book series publishes review articles discussing important aspects in research and in clinics in the field of cardiac and vascular biology. Basic research aspects of medically relevant topics are covered and the latest advances and methods from diverse disciplines such as genetics, epigenetics, mechanobiology, platelet research or stem cell biology are featured.
Cardiovascular Repair › Institute of Cardiovascular ~ Boon RA, Iekushi K, Lechner S, et al. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495(7439):107-110. Bonauer A, Carmona G, Iwasaki M, et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009;324(5935):1710-1713.
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Cardiac Biology / Cardiovascular Research / Oxford Academic ~ Cardiac Biology. Back to Image Library. Refining the molecular organization of the cardiac intercalated disc. Sarah H. Vermij, Cardiovasc Res (2017) 113(3) doi: 10.1093/cvr/cvw259. Figure 1. Old model of the cardiac intercalated disc, in which adherens junctions, desmosomes, and gap junctions are independent structures.
Cardiac regeneration: current therapies—future concepts ~ Jackson KA, Majka SM, Wang H, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001;107:1395-402. Franco D, Moreno N, Ruiz-Lozano P. Non-resident stem cell populations in regenerative cardiac medicine. Cell Mol Life Sci 2007;64:683-91. Nombela-Arrieta C, Ritz J, Silberstein LE.
Cardiac regeneration strategies: Staying young at heart ~ The human heart is continually operating as a muscular pump, contracting, on average, 80 times per minute to propel 8000 liters of blood through body tissues each day. Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least in mammals, has poor regenerative potential. This deficiency is attributable to the lack of resident cardiac stem cells, combined with .
Cardiac Regeneration / Global Events /USA/ Europe / Middle ~ Cardiac Regeneration. The regrowth of organs and tissues of the heart that are lost in an injury are called Cardiac Regeneration.This is in disparity to wound healing, which involves closing of the injury site by forming a scar.
Cardiac muscle regeneration: lessons from development ~ The cardiac cell cycle as a therapeutic target. Conceptually, one might approach the task of augmenting cardiac muscle cell number by antagonizing cell death (Fig. 1; for review, see Whelan et al. 2010).Success in mice has been achieved by numerous genetic interventions that interfere with the machinery for apoptosis, necrosis, and autophagy (Pattingre et al. 2005; Nakayama et al. 2007; Diwan .
A major step towards cardiac muscle regeneration / Harvard ~ Cardiac progenitors were used to engineer 2-dimensional cardiac tissue into a muscular thin film (MTF). To measure contractility,the MTF was fixed as a cantilever on one end and the contracting cells bent the MTF toward the cell-side during contraction.The force generated by this ESC-derived MTF was similar to MTFs engineered from neonatal cardiac muscle cells.
Cardiac regeneration and repair - 1st Edition ~ Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy.. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function.
Heart regeneration and repair after myocardial infarction ~ Ellison, G. M. et al. Adult c-kit + cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 154 , 827–842 (2013). CAS PubMed Google Scholar
Cardiac Progenitor Cells in Basic Biology and Regenerative ~ Review Article Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine Nevin Witman1,2 and Makoto Sahara 1,2 1Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden 2Department of Medicine-Cardiology, Karolinska Institutet, 171 77 Stockholm, Sweden Correspondence should be addressed to Makoto Sahara; makoto.sahara@ki.se
REVIEW Cardiac regeneration strategies: Staying young at heart ~ Cardiac regeneration strategies: Staying young at heart . 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, . supporting vascular cells, and/or cardiomyocytes to create engineered contractilecardiacpatches—canbetterreplicate
Vascular regeneration › Institute of Cardiovascular ~ Our group is interested in the process leading to vascular regeneration and the control of the vascular niche upon acute injury, chronic disease states and in aging. Using genetic lineage tracing of endothelial cells, we fate mapped the origin of the endothelial cell in the vascular network and showed that endothelial cells clonally expand (Manavski et al, Circ Res 2018 1 ).
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Concise Review: Heart Regeneration and the Role of Cardiac ~ Cardiac stem/progenitor cell‐based regeneration in the adult mammalian heart. The proposed mechanism of cardiac regeneration mediated by endogenous CSCs present in the heart is shown. This mechanism is based on the observation that cardiac stem/progenitor cells (CSCs) are multipotent (A), self‐renewing (B), and clonogenic (C).
Heart Regeneration with Engineered Myocardial Tissue ~ Recent advances in cardiac and vascular tissue engineering will move us closer to the goal of generating functionally mature tissue. Using the biology of the myocardium as the foundation for designing engineered tissue and addressing the challenges to implantation and integration, we can bridge the gap from bench to bedside for a clinically tractable engineered cardiac tissue.
Cardiac Regeneration and Repair - 1st Edition ~ Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.